POS0039 MRI LESIONS IN SPA: A COMPARISON WITH AGE AND SEX MATCHED PARTICIPANTS WITH NON-INFLAMMATORY BACK PAIN

Background: Magnetic resonance imaging (MRI) is becoming increasingly important in axial spondyloarthritis (SpA) due to its unique role early diagnosis, classification, and monitoring of disease (1, 2). It the only assessment tool that has been validated with histological inflammatory cellularity tissue biopsy sacroiliac (SI) joint (3). However, many MRI lesions are not exclusive SpA may occur other conditions such as infection, degeneration malignancy. Further characterization these guide more targeted therapies. Objectives: The objective this study was describe, investigate associated factors, compare individual age sex matched controls. Methods: This a cross-sectional observational 431 participants compared 53 non-inflammatory back pain. Individual identified included: discovertebral (DVL), facet lesions, costovertebral corner (CIL), fatty (FCL). Associated factors were determined by regression analyses. Results: Compared control group, had (12.5% vs 1.9%; p=0.02), CIL (46.6% 15.1%; p=0.03), FCL (55.5% 39.6%; p=0.03). Multivariate showed (OR=1.02; regular alcohol use (OR=0.40; p=0.04) radiographic (OR=1.89; p=0.01) DVL; Chinese ethnicity (OR=0.06; (OR=3.63; lesion; (OR=4.26; p<0.001) male gender (ß=1.10; p=0.01), HLA B27 (ß=1.02; (ß=1.05; CIL; (ß=0.10; p<0.01), (ß=1.96; body weight (ß=0.11; (ß=3.23; p<0.001), (ß=1.77; p=0.02) FCL. Conclusion: specific when pain CIL, References: [1]Mandl P, Nacarro-Compan V, Terslev L, Aegerter van der Heijde D, D’Agpstino MA, et al. EULAR recommendations for diagnosis management clinical practice. Ann Rheum Dis. 2015;74(7): 1327-39. [2]Ostergaard M, Lambert RG. Imaging ankylosing spondylitis. Ther Adv Musculoskeletal 2012;4(4):301-11. [3]Bollow Fischer T, Reisshauer H, Backhaus Sieper J, Hamm B, Quantitative analyses biopsies spondyloarthropathies: T cells macrophages predominate active sacroillitis - correlates degree enhancement detected magnetic imaging. 2000;59(2):135-40. Disclosure Interests: None declared.